The team has extensive experience modeling neurological diseases in small and large animals. Several unique models have been established that are particularly suitable for testing the biodistribution and efficacy of drugs delivered to the brain. The team has established tools for the transient opening of the blood-brain barrier, modeling stroke in swine using the minimally invasive endovascular technique, modeling human brain tumors in immunocompetent animals. Multimodality imaging is being used for precise delivery and quantitative monitoring of drug accumulation in the brain.
A second major component is the utilization of biomaterials for medical applications including transplantation of stem cells for brain repair and various other therapeutic strategies. The group specializes in performing therapeutic interventions with monitoring of multimodality imaging. One of the team's latest achievements is the co-invention of a patented solution based on manganese labeling of biomaterials facilitating image-guided delivery. This platform will contribute to the precise deposition of various therapeutic agents, including cells, viruses, proteins, and others.