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STROKE 

MODEL

IN SWINE

Minimally invasive endovascular approach for inducing ischemic stroke with longitudinal MRI during and after ischemia.

 

Catheter placement in cerebral artery gives opportunity for targeted delivery of therapuetics immdiately after stroke. 

Publication
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FOCAL 

DEMYELINATION 

IN SWINE

Precise placement of demyelinating lesion in any location within swine brain.

 

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Opportunity for testing drug efficacy in highly reproducible model with monitoring therapy using longitudinal MRI. 

Publication
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GBM

MODEL IN RODENTS

Human glioblastoma in immunocompetent mice/rats based on induction of immunological tolerance.

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Opportunity for testing biologics in the context of intact immunity with targeted delivery across osmoticaly opened BBB. 

Publication
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Fresh

FOCAL 

DEMYELINATION 

IN RATS

Precise placement of demyelinating lesion at any location within rat brain. 

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Opportunity for cost - effective testing drug efficacy in highly reproducible model with longitudinal MRI. 

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*ALL ANIMAL EXPERIMENTS ARE PERFORMED ACCORDING TO THE HIGHEST STANDARDS BY HIGHLY EXPERIENCED PERSONEL AND ONLY WITH APPROVAL BY A LOCAL ETHICS COMMITTEE.  LONGITUDINAL STUDIES WITH NON INVASIVE IMAGING HELP REDUCE NUMBER OF EXPERIMENTAL ANIMALS WHICH IS IN ACCORDANCE WITH 3R RULE. 

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